Modeling Epilepsy in a Dish Using Patient-Derived iPSCs

Epilepsy is one of the most common neurological conditions, affecting over 65 million individuals worldwide, and is characterized by recurrent, spontaneous, and uncontrollable seizures. Seizures commonly arise in the epileptic brain after a sudden burst in neurological activity. While many anti-epileptic drugs control seizures, one-third of patients with epilepsy fail to respond to them. Managing drug-resistant epilepsies poses a challenge to scientists and clinicians alike.

In this episode, narrated by Niki Spahich, Sejal Davla from The Scientist's Creative Services Team spoke with Evangelos Kiskinis, an assistant professor at Northwestern University Feinberg School of Medicine, about his work modeling drug-resistant epilepsies using induced pluripotent stem cells (iPSCs), a technique that offers novel disease management solutions that could translate to the clinic.

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The Scientist Speaks is a podcast produced by The Scientist’s Creative Services Team. Our podcast is by scientists and for scientists. Once a month, we bring you the stories behind news-worthy molecular biology research. This month's episode is sponsored by Axion BioSystems and 10x Genomics.


Evangelos Kiskinis, PhD
Assistant Professor Neurology and Physiology
Robertson Investigator, New York Stem Cell Foundation
Scientific Director, Stem Cell Core Facility
Northwestern University Feinberg School of Medicine
Sponsored by Millipore Sigmas

Axion BioSystems' innovative Maestro platform effortlessly captures and quantifies complex biological functions. Whether modeling neurological disease or developing advanced cancer immunotherapies, the Maestro platform delivers sensitive, real-time results to empower your research.

10x Genomics 10x

This episode is brought to you by 10x Genomics, which builds solutions for interrogating biological systems at a resolution and scale that matches the complexity of biology. Their rapidly expanding suite of products, which includes instruments, consumables, and software, enables fundamental discoveries across multiple research areas, including cancer, immunology, and neuroscience.

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