A Better Way to Detect Protein Aggregation

Early detection with microfluidic modulation spectroscopy (MMS) addresses protein instability and loss of function.

Detecting protein aggregation is important for all stages of drug development as it indicates protein instability and potential loss of function. Researchers use microfluidic modulation spectroscopy (MMS), an infrared spectroscopy technique, to characterize protein secondary structures that detect early-onset protein instability. MMS does this by measuring minute changes in antiparallel beta sheet composition, which is an indicator of irreversible aggregation.

Download this application note from RedShiftBio to explore how MMS technology detects changes in protein aggregation at different drug development stages, including formulation screening, manufacturing, and storage.