LabTools_Cytokine-Signaling-1.png
If you have already registered, please check your email for the webinar link.

Event Overview

Sensory experience sculpts neural connectivity via cellular and molecular mechanisms that are still largely unknown. Through a combination of single-cell transcriptomics, structural analysis, and electrophysiology, Dr. Lucas Cheadle and colleagues identified the secreted cytokine TWEAK and its receptor Fn14 as important regulators of sensory-dependent synaptic remodeling. Hear from Cheadle about his use of multiplexed mRNA detection in situ with spatial resolution to reveal temporally coordinated, experience-dependent expression of TWEAK in microglia and Fn14 in excitatory neurons, suggesting that experience regulates circuit development by initiating complementary transcriptional programs in neuronal and non-neuronal cells. This webinar is sponsored by Advanced Cell Diagnostics.

Topics to be Covered
  • Single-cell transcriptomics and in situ validation of sensory-driven gene expression
  • Sensory experience-dependent refinement of neural circuits by transcriptional control in activated neurons
  • Induction of TWEAK expression in microglia by sensory stimulation
Tuesday, January 22, 2019
 
2:30 - 4:00 PM Eastern Time


Speakers

Cheadle_headshot
Lucas M. Cheadle, PhD
Postdoctoral Fellow (Greenberg Lab), Department of Neurobiology
Harvard Medical School

Courtney_Anderson
Courtney Anderson, PhD
Research Manager, Applications
Advanced Cell Diagnostics


ACD Bio.png

Register Now

Already Registered?

TS_WEBINARSIGNUP_Regulation of Sensory-dependent Circuit Refinement by TWEAK/Fn14 Cytokine Signaling

You must have Javascript and Cookies enabled to access this webcast.

Information you provide will be held in confidence and will be shared with the sponsoring vendor(s) of this webinar. We may use the information to contact you about your account and to let you know about related programs and products; you may opt-out at any time. This allows The Scientist to keep these webinars free of charge for our readers.